Sertraline Withdrawal

What is Sertraline Withdrawal?

Sertraline belongs to the category of medicines known as selective serotonin reuptake inhibitors. It is used for the treatment of panic disorders, obsessive compulsive disorders and depression. It affects the balance of the natural chemicals present in the brain and works by increasing the amount of the neurotransmitter serotonin in the brain, by preventing its reuptake. This reduces panic attacks, improves mood and treats OCD. With prolonged consumption, the brain gets used function in its presence and the person can get addicted. However, sertraline withdrawal can be difficult as the person finds it difficult to cope up with the absence of the drug.

Sertraline 25 mg
Image Source: Sertraline 50 mg
Image Source: Sertraline Hydrochloride 100mg
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Sertraline Withdrawal Symptoms

  • Anxiety
  • Crying spells
  • Fatigue
  • Insomnia
  • Cramps
  • Brain zaps
  • Memory loss
  • Flu like symptoms
  • Headaches
  • Irritability
  • Depression
  • Confusion
  • Decreased appetite
  • Depersonalization
  • Weakness
  • Suicidal thoughts
  • Panic attacks
  • Mood swings
  • Poor concentration
  • Anger
  • Dizziness
  • Sleepiness


  • Tests should be done to find out what kind of toxin is affecting
  • Any psychological causes like stress, depression, anxiety, etc. need to be revealed or established to finalize a treatment.
  • Medical history of the patient must be known to the doctor.
  • Knowledge about the pattern of use by the patient, with regard to dosage and frequency is essential.


  • The dosage of the drug must be lowered gradually instead of immediate discontinuation or cold turkey. Tapering would hence help in preventing or moderating the symptoms associated with the withdrawal.
  • Alternatives to the medication are also prescribed.
  • Therapies must be practiced to release stress and provide relaxation to the patient.
  • Healthy eating and habits are essential for good results of the treatment.
  • People must inculcate healthy habits like exercising and meditating to keep the body healthy.


  • Consumption of the medication along with any other substances must be avoided.
  • A doctor must be consulted to determine the treatment procedure to ensure that the patient is treated correctly.

How long does it take for to sertraline detox?

Sertraline remains in the system for about 11 to 12 days and its metabolite stays in the system for about 25 to 30 days. However, the symptoms of withdrawal emerge only after the system is clear. The withdrawal symptoms can last for over 3 months.

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